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  References:

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• PedsElite, 1 novembre 2025 @ 0h17

  For instance, spermatogenesis could nonetheless occur with hCG usage regardless of undetectable
  FSH and LH circulating levels (Smit et al., 2020; Bond et al., 2022).
  Specifically, hCG probably preserves spermatogenesis throughout gonadotropin suppression (Matsumoto et al., 1986).
  As demonstrated right here, it is highly difficult
  to research the overall results of polypharmacy and the use of unknown or hidden substances, so its potential anecdotal advantages and dangers remain largely unknown. Due To This Fact,
  the real-world of AAS abusers is very advanced, making it
  difficult to elaborate evidence-based recommendations for the
  prevention and management of AAS antagonistic
  events. In men, the medications will help to control the discharge of FSH and LH, that are essential
  for high quality sperm manufacturing.
  However, there are some issues regarding the relationship between train supplements these designed for serving to build muscle, and male fertility.
  The commonest unwanted effects of steroid use that happens
  in women need to do with a lower in female aspects and the looks of male
  characteristics. Dealing with the reproductive consequences of steroids
  can be overwhelming and disheartening, especially for these who are keen about bodybuilding.
  But the first step to overcoming that feeling is understanding tips on how to shield your reproductive well being.
  Completely, and pure dietary supplements play
  a job in this context, highlighting the need
  for careful consideration of all substances being used.
  It’s crucial to research and understand the potential unwanted
  aspect effects of any supplement. In addition to reducing sperm counts, steroid abuse can really
  make the testicles shrink.
  The concerted motion of LH and FSH on the testes stimulates spermatogenesis, and suppression of
  these hormones inhibits it. FSH acts directly on spermatogenesis by activating FSH receptors on Sertoli cells, whereas LH works indirectly by way of stimulating testosterone production by activating LHCGRs on Leydig
  cells, which in flip prompts ARs on Sertoli cells (179).
  Regardless Of testosterone being the first mediator of LH’s effect on spermatogenesis,
  exogenous administration of testosterone can’t assist
  spermatogenesis. Intratesticular testosterone (ITT) levels are about 50 to 100 times greater than in circulation (180) and exogenous administration severely suppresses this to ranges that
  are unable to assist spermatogenesis (181). The key question that is still to be answered is
  whether high dosages of AAS additional promote the event of male-pattern hair loss.

  In the HAARLEM examine, self-reported alopecia increased
  from 2% at baseline to 12% at the end of the cycle (39).
  The research did not embody an goal measure of alopecia,
  which makes it difficult to tell apart between a real rise in incidence and a mere self-perceived
  one.
  One notable exception is nandrolone, which is converted into dihydronandrolone (DHN) by 5α-reductase.
  Nonetheless, whereas testosterone is transformed into the more potent androgen DHT by 5α-reductase (21), the conversion of nandrolone into DHN yields an androgen with considerably decrease binding
  affinity for the AR (77, 78). Thus, whereas testosterone’s actions might be amplified in tissues expressing 5α-reductase, nandrolone’s actions may be
  diminished (21). On the premise of this metabolism, the mixture of a
  5α-reductase inhibitor with nandrolone appears particularly
  misguided. To manage this aspect impact, some AAS users resort to ancillary medication for therapy.
  This consists of use of the oral prescription drug isotretinoin by a small share of users (65, 67).

  The challenge with studying the antagonistic results of AAS is that there have been treasured few scientific trials learning the implications of those compounds in humans [41,forty two,forty three,forty four,forty five,forty six,forty seven,48,49].
  Most research reporting opposed results from AAS have been retrospective and anecdotal in nature
  with no standardization of beforehand used substances or dosing regimens [39,49].

  The progressive use of both transmission electron microscopy and
  fluorescence in situ hybridization (FISH) has just lately been reported in an AAS consumer sperm pattern,
  looking for genetic and ultrastructural consequences of steroid abuse.

  Immaturity, necrosis and apoptosis were assessed, and a excessive
  proportion of structurally regular spermatozoa had been found, which showed
  the absence of a correlation between AAS and ultrastructural sperm changes.

  We know that there’s a important gap in the schooling of young people round
  fertility and you’ll guarantee that they don’t absolutely understand the implications of AAS use on their sperm health, reproductive well being and common well being.
  Animal research have shown that the variety of Leydig cells within the testicles drops
  significantly as a outcome of AAS use. Leydig cells are
  the primary source of androgens and testosterone in men and are crucial for sperm production and spermatogenesis.

  Research have shown that Leydig cell numbers do improve after AAS use
  stops, however numbers don’t all the time return to beforehand seen ranges.

  While many effects of steroid use on fertility may be reversible,
  there are potential long-term complications to
  think about. Chronic use of anabolic steroids can result in everlasting damage to the ovaries and other reproductive
  organs. Conditions corresponding to polycystic ovary syndrome (PCOS) could be exacerbated by steroid use, resulting in prolonged infertility
  and different health points. Anavar, also called Oxandrolone, is a
  well-liked anabolic steroid that was initially developed in the Nineteen Sixties to help
  sufferers achieve weight after surgery or persistent
  sickness. Over the years, it has gained a following,
  notably among female athletes and bodybuilders, who recognize its potential for selling
  lean muscle mass with out extreme weight acquire.
  ” it’s essential to delve into its results and how it interacts with the feminine body.
  Men with hypogonadotropic hypogonadism might experience a variety of symptoms due to low ranges of testosterone. These can include decreased libido, erectile dysfunction, fatigue, loss of muscle mass, and an increase in physique fat. When anabolic steroids are launched into the body, they will inhibit the discharge of GnRH, resulting in a lower in LH and FSH, and consequently, a discount in testosterone and sperm manufacturing. By mimicking testosterone, anabolic steroids trick the physique into believing it has adequate or excessive ranges of this hormone, leading to a lower within the manufacturing of gonadotropin-releasing hormone (GnRH). Over the final decade, the abuse of anabolic steroids has increased, there have been extra deaths which have affected both male and female bodybuilders. The use of AASs enhances muscle progress and increases power, thereby improving athletic performance.
  The isovolumic relaxation time can be an unbiased predictor of heart failure in the common inhabitants (219). Consequently, an argument could probably be made to understand these AAS-induced cardiac changes as risk modifiers when estimating CVD risk using algorithms similar to SCORE2 or PCE, and will aid in ‘grey zone’ threat estimation situations. Serum creatinine levels are generally used to estimate the glomerular filtration rate (eGFR) using formulation such because the Persistent Kidney Illness Epidemiology Collaboration (CKD-EPI) equation (157). The eGFR is an effective and impartial predictor of all-cause and cardiovascular mortality and kidney failure in a wide range of populations (158). Nevertheless, it ought to be appreciated that the accuracy of the equation is predicated on the assumption that serum creatinine levels accurately replicate the GFR – which is uncertain in this explicit population. Creatinine is, for essentially the most half, a product of the spontaneous nonenzymatic degradation of creatine (Cr) and creatine phosphate (PCr) (159). The total conversion fee for the total Cr pool (Cr + PCr) is (almost) fixed and roughly 1.7% day by day.

  References:

  PedsElite

• Muscle maintenance stacking, 1 novembre 2025 @ 1h22

  After the 2003 season, which was in all probability my most profitable season on record, I had great results, had a giant Tour de France.
  I got again stateside after the season was over, it was in my off-season, and I realized
  I was having a hard time just getting away from bed, no motivation. I imply,
  I thought of suicide, I drank to only check
  out at some points. Fairly a lot every night, if not every night time at least each other night, I’d get up usually between two and three
  in the morning and just sit there for forty five minutes and stare on the ceiling.
  I referred to as them committee conferences and just type of think about what I was up to and
  the implications if it all went unhealthy,
  how ugly that was going to look.
  The term ‘anabolic androgenic steroids’ refers to the anabolic (muscle building) and androgenic (virilising) results of
  those compounds. Injectable testosterone esters are among the many AAS most used, however there might be
  all kinds of artificial derivatives out there. Testosterone, as most different AAS, undergoes intensive metabolism when administered orally.

  Subsequently, some AAS have been alkylated to extend bioavailability after oral administration.
  However, many years in the past, it turned evident that
  17-alkylated androgens are hepatotoxic and scientific application was
  largely deserted (5). Although most AAS abusers are well
  aware of this, oral AAS, corresponding to methandienone (Dianabol), chlorodehydromethyltestosterone (Turinabol), oxandrolone (Anavar) and
  stanazolol (Winstrol), are nonetheless extensively abused.
  With Out modification, steroids quickly enter the blood,
  resulting in excessive peak levels and a very short plasma half-life.

  Right Here are six potential unwanted effects of anabolic steroids when they’re taken at excessive doses and absent
  a transparent medical indication. The unwanted side effects of Equipoise can include high blood pressure and excessive ldl cholesterol, but each ought to be straightforward to manage.
  If the individual controls water retention, which should
  not be onerous to do with this steroid, hypertension shouldn’t be
  a problem baring some underlying factor. Then we have ldl cholesterol, and whereas
  this is not an especially unfriendly steroid to cholesterol
  it could possibly have a negative impact. The
  unwanted effects of Equipoise revolving around ldl cholesterol must be far less problematic than the vast majority of anabolic steroids, but significant suppression of HDL ldl cholesterol (good cholesterol) is possible.

  If you’re trying to construct muscle and enhance athletic performance, the safest alternatives are these that don’t rely on drugs and dietary supplements.
  Contemplate speaking with a dietitian and/or
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  and stamina as a substitute. From sinus infections and hypertension to preventive screening,
  we’re here for you. There’s also analysis on Australian males highlighting unwanted effects like aggression, violent
  behaviour, and impulsivity regulation issues, and the impression Tren can have on psychological health and relationships.
  At Advantage Recovery Heart, we’re right
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  Deca is medically very helpful for treating osteoporosis and loss of bone tissue.
  This reveals its energy on this division, due to its capacity to
  increase bone mass and stimulate pink blood cell formation in bone marrow.

  Deca-Durabolin has extensive benefits for joint strength and bone health.
  This is all because of its capacity to promote collagen synthesis for strengthening joints and connective tissue.
  Most Deca-Durabolin customers will discover this effect more than with other steroids, including a notable discount in joint ache and basic aches and pains.
  Its therapeutic outcomes are as necessary, though not physically apparent, as your dimension gains or body recomposition. Efficiency athletes may also benefit from strengthening and
  healing joint and connective tissue.
  If you’re injecting steroids, you’re also vulnerable to contracting blood-borne viruses corresponding
  to HIV, tetanus or Hepatitis C or B. Injecting can also cause abscesses (a pocket of pus) and blood
  clots if the approach is inaccurate or you’re repeatedly injecting
  the same space. Deca-Durabolin has a half-life of days because of the
  slower-acting decanoate ester hooked up to the Nandrolone
  hormone. However, it has a protracted detection time, up to
  18 months after your ultimate dose. Each forms of Nandrolone hormone are
  the identical as these two steroids, however they’ve a unique ester hooked up.

  It’s value noting that while HGH can provide these benefits, its effects on athletic efficiency usually are not as
  pronounced as these of anabolic steroids. Some research recommend that HGH
  could provide performance-enhancing benefits, however the evidence
  is not conclusive. For these new to utilizing
  anabolic steroids, Primobolan is usually thought-about one of many
  most secure choices for newbies. Its gentle nature and lower
  threat of side effects make it a beautiful alternative for these looking to expertise the advantages of steroids with minimal antagonistic reactions.

  In Accordance to the Advisory Council on the Misuse of
  Medicine report, counterfeit steroids don’t comprise the dose specified, may be contaminated with micro
  organism, and should embody unknown and potentially dangerous substances.
  Medically, anabolic steroids can treat hormonal issues, certain cancers, osteoporosis,
  and other uncommon situations. Outside of medication, each women and men use steroids to improve athletic efficiency and alter
  bodily look by increasing muscle mass and decreasing body fats.

  If you’re contemplating using anabolic steroids to boost muscle mass or athletic performance,
  it’s vital to recognise the potential for vital
  side effects and habit. The most secure route is to avoid anabolic steroids altogether,
  but when you determine to make use of them, there are steps to minimise the adverse impact they can have on your well being.

  “A tiny bit extra physique hair after a few years”
  is a notable comment from a girl utilizing
  EQ year-round in a cruising and blasting protocol.
  It’s no surprise in any respect that this steroid has been (illegally) utilized by some elite athletes.

  This is probably considered one of the greatest efficiency steroids we can use,
  and the primary cause for its unbelievable ability to supercharge your cardiovascular efficiency
  is because of the way in which it increases purple blood cell count (sometimes too much).
  Men on anabolic steroids could expertise baldness, breast growth,
  and shrinking testicles, based on MedlinePlus.

• The Impact of Dosage on Testosterone Cypionate Effectiveness, 1 novembre 2025 @ 2h00

  Each girl may have a unique tolerance regarding how a lot negative effect she is keen to deal with.

  The most hardcore female bodybuilders will have a high tolerance for more extreme unwanted facet effects and may not even be overly bothered by this.
  Nonetheless, suppressing the development of male characteristics as a lot as possible for lots
  of other women might be a high priority in the course of the cycle.
  This is the place getting the dosage right can make
  all the difference, and so will minimizing cycle size.

  A Clenbuterol cycle ought to be quick and start
  at a low dose, especially if it’s your first time.
  You will need to consider your response to this drug earlier than raising the dose.

  He also adds that approximately 30% of people develop dependency
  syndrome as a consequence of using anabolic steroids.
  In this case, our patient’s body temperature increases by
  roughly 1 degree. We find that fat loss ceases approximately 4-6 weeks into a cycle when the
  body inevitably reaches homeostasis and cools down.
  Development hormone and follicle stimulating hormone (FSH) are among the hormones that stimulate testis and ovary function and are two of the various
  hormones secreted by the pituitary. Side results to anticipate with
  this steroid embrace testosterone suppression, mild negative influence on cholesterol, and comparatively low danger of androgenic effects in males like hair loss
  and pimples. Equipoise has a low degree of estrogenic activity, so these unwanted facet
  effects ought to be simple to manage. Still, they’ll embrace water retention and gynecomastia, particularly when the
  steroid is used at higher doses. Women can use Equipoise at low doses with a low danger of virilization effects.
  If you’re going to run an EQ cycle, try my full Equipoise (Boldenone) cycle
  guide. Oxymetholone is used medically to treat osteoporosis, anemia, and wasting syndrome.

  This provides you very little time to gain the
  advantages of any steroid. This means such a
  short cycle might be favored by individuals with
  specific reasons to run a cycle of this size quite than a regular
  one. You can use the identical ancillary compounds because the
  week cycle plans, though you won’t get some advantages that need a longer cycle.

  There are numerous forms of corticosteroids, which may be taken topically or through inhalation, with others
  being administered by injection or oral tablets. Steroids could weaken your immune system
  and enhance your threat of side effects from reside vaccines.
  Discuss together with your physician about another medicines,
  dietary supplements, and herbal remedies you currently
  take to stop possible interactions with steroids. It’s essential to assume about all
  the following risks and to discuss any concerning
  symptoms together with your doctor. However, prescription steroids
  must solely be used by the particular person a well being care provider ordered them for.

  Diuretics are drugs that change the physique’s stability
  of fluids and salts. They can cause the body to lose
  water, which may lower an athlete’s weight. Diuretics also may assist athletes cross drug exams that examine for indicators of medication within the urine.
  It additionally raises the degrees of the protein in purple blood cells that carries oxygen to the body’s organs, referred
  to as hemoglobin. Some drugmakers and workout magazines declare that andro products help athletes train tougher and recover quicker.

  Androstenedione, additionally referred to as andro, is a hormone everybody’s physique makes.

  Nevertheless, as with different side effects, this
  elevated aggression will affect customers to totally different levels.

  This may depend upon a person’s genetics and conduct earlier than taking anabolic steroids.
  Thus, if an individual is vulnerable to violent acts or murder
  is present of their family history, steroids corresponding to Dianabol
  might exacerbate this. The bodybuilder and TikToker
  David Rau (25,600 followers) has been open about his experience.
  Anadrol can considerably suppress testosterone levels, necessitating post-cycle therapy to reestablish regular testosterone
  function. Failure to employ effective post-cycle therapy can result in gonadal
  deficiency for a quantity of months or completely if anabolic steroids are abused.
  Analysis signifies that testosterone also can negatively affect high-density lipoprotein (HDL) and low-density lipoprotein (LDL) ldl cholesterol ratios, doubtlessly inflicting hypertension (high blood pressure) (2).

  The following is an aggressive PCT protocol designed by Dr.
  Michael Scally, a number one skilled in hormone substitute.

  This was used in a medical setting on 19 males, in which
  one hundred pc of them recovered their natural testosterone manufacturing 45 days after taking steroids.
  PCT (or post-cycle therapy) is a crucial interval the place bodybuilders will attempt to recover their
  natural testosterone production whereas trying to retain as a lot muscle and power from their
  cycle as potential. Zits is a typical side impact that approximately 50% of bodybuilders expertise because of using anabolic steroids (25).
  When testosterone increases, low-density lipoprotein (LDL) levels of cholesterol
  also improve. LDL is the unfavorable sort of ldl cholesterol that
  can clog arteries when high, resulting in a spike in blood pressure.

  Thus, the liver will almost actually turn out to be broken during a cycle of Dianabol.
  Nevertheless, The Impact of Dosage on Testosterone Cypionate Effectiveness draw
  back to Dianabol being proof against such hepatic breakdown is increased hepatotoxicity.

  Dianabol (methandrostenolone) doesn’t just aromatize; it also converts to 17 alpha-methylestradiol, which is essentially a
  type of estrogen significantly more potent than estradiol.

  This conversion, combined with its existing aromatizing attributes, creates a reasonably estrogenic compound.
  We have found it to be a potentially harmful compound, especially when used irresponsibly
  or not underneath a doctor’s supervision.
  T3 hastens your fats loss and makes it simpler to lose fat; this is the core use of this hormone and a very specific use.

  It is a low-cost drug that’s typically simple to
  search out and is tolerated well by most individuals when used inside the recommended
  dosage vary. If you’re going to run a T3 cycle, check out my full Cytomel (T3)
  cycle information. For slicing functions,
  a better dosage holds little profit but a higher threat of side
  effects. Therefore, as little as 200mg weekly, up to 400mg weekly is recommended.
  An 8-week slicing cycle with Equipoise is recommended, together with in case you are
  doing a longer cycle with different compounds; use EQ for the primary eight weeks.

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  After which they’d decline to hypogonadal states and even decrease than earlier than they began testosterone alternative therapy.
  This yo-yo remedy was merciless and unfair but unfortunately, many
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  responds to therapy and attaining a steadiness that mimics
  natural hormone levels. Finding the optimal dosage is essential for maximising advantages whereas minimising potential
  unwanted facet effects. Historically, TRT dosages were primarily based on manufacturer tips,
  typically leading to fluctuating testosterone levels and inconsistent results.
  Many males nonetheless endure sub-optimal treatments from the NHS and inexperienced non-public consultants.

  It’s straightforward to suppose that by calculating the
  half-life of a steroid, you probably can work out when it’s going
  to now not be detectable in your body, and you can then pass a drug test with flying colours
  – right? With newer scientific advances, anti-doping testing can detect long-term metabolites higher than ever.
  Breakthroughs have resulted in detecting specific
  steroid metabolites for twice so long as previously attainable.
  This signifies that only remaining traces of metabolites could slip past the
  drug testing strategies; these traces can now be picked up to return a positive outcome.
  Testers will usually take a look at for all known steroids, but when assets are
  limited, then solely probably the most commonly used steroids shall be examined for.
  As A Outcome Of the testing has to target a selected steroid, the method should
  include each possible steroid to cover all bases.

  GGT and bilirubin levels in serum do not appear to increase in response to
  exercise (111). The membrane-bound enzyme GGT is expressed within the kidneys, pancreas, spleen,
  lungs, mind, intestines, coronary heart, prostate and liver – where it’s
  mainly expressed in areas that are rich in biliary epithelial cells (112).
  An improve in GGT is a delicate measure of cholestatic liver
  disease (113). The collective enhance in these serum markers ought to thus be interpreted as a sign of liver harm, even within the presence
  of concomitant muscular train. In managed trials,
  scientific signs of liver damage because of AAS use are certainly rare.
  In a double-blind randomized-controlled trial, solely certainly one
  of sixty one HIV sufferers receiving a excessive dosage of 100–150
  mg oxymetholone (a 17α-alkylated anabolic steroid) daily developed jaundice over the
  course of sixteen weeks (107).
  Bodybuilders and athletes typically use them to construct muscle
  mass rapidly, bulk up, and reduce. The great attraction of SARMs
  is that they will present outcomes similar to steroids however with zero side effects and no want for PCT.
  Clomid isn’t without dangers of unwanted aspect effects like sexual dysfunction,
  temper points, and even despair in SOME customers. Enclomiphene appears to be a milder
  drug when it comes to unwanted facet effects
  but probably even higher at stimulating testosterone recovery.
  Suppose you need to lower your risk as much as possible of impacting
  your natural testosterone sooner or later, together with your fertility.
  Do common cycles and PCT, then think about how you’d really feel about injecting testosterone to retain normal hormonal operate for the relaxation of your life.
  If your acne is likely brought on by DHT, lowering DHT ranges is your starting point.

  Most oral cycles additionally include longer-lasting injectables, so your choice
  on WHEN to start PCT should depend on the longest-lasting compound in your cycle.
  The typical 2-week wait before beginning PCT with SERMs is the ideal place to begin; there are issues to contemplate throughout that point.
  The TRT cruise in between cycles goes to hold up
  your testosterone function. Most users find it easy to take care of gains
  when blasting and cruising, but it’s a long-term dedication. Excessive prolactin can impact your sexual health, most notably a major
  lower in libido and erectile perform.
  It’s merely a matter of following the advice above and making use of dopamine agonists and/or P-5-P B6.
  The dosage guide above is suited for Nandrolone doses as much as
  200mg, but you may want to extend your dopamine agonist dosage when taking higher doses of
  steroids. Acne is a horrible androgenic facet impact that
  nobody wants to develop. You might be lucky to have
  zero tendency to develop zits, no matter what steroids you employ.
  At the opposite end of the spectrum are guys who start breaking out even at low doses of delicate steroids.
  Your only possibility for hair loss prevention shall be
  RU-58841, as Finasteride may have no impact. You’ll use RU
  by applying it immediately the place it’s wanted, and it really works in these
  particular spots by blocking those androgen receptors.
  Designed to supply accurate outcomes for better health tracking
  and hormonal steadiness. Testosterone Cypionate might cause hair loss sooner than should you weren’t utilizing the steroid and will
  usually be everlasting. A 5-alpha reductase inhibitor
  drug can block DHT and probably scale back hair loss whereas
  using Testosterone Cypionate. Nevertheless, hair loss remains to be possible even with out excessive ranges of
  DHT because testosterone itself is a strong androgen. Countless men can tolerate Testosterone Cypionate
  doses near and even nicely above 1000mg per week and undergo
  little or even no unwanted side effects – even when utilizing the steroid for very long cycles.
  Others can discover lower doses encourage the event of unwanted
  androgenic results, which is generally a matter of genetics (in different words, luck!).

  In Contrast with serum creatinine, serum cystatin C concentrations are much
  less affected by age, intercourse, race, and, most significantly,
  muscle mass (167). One research so far has investigated the effect of excessive dosages of
  AAS on serum cystatin C concentrations (168).
  Serum creatinine and cystatin C concentrations have been measured in 57 present AAS users, 28 past
  customers, and fifty two non-AAS-using weightlifters.

  References:

  Comprehensive Trenbolone Pills Analysis

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